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DHEA is the most abundant steroid hormone produced by the adrenal glands. Once synthesized, it is converted into androgens, estrogens, and other hormones depending on an individual’s age, sex, and metabolism. These hormones play critical roles in regulating metabolism, reproductive health, and energy levels.
DHEA production peaks by age 25 and gradually declines with age. It is also produced in smaller amounts by the liver, brain, and in men, the testes. It primarily converts to androstenedione, which serves as a precursor to both estrogens and androgens.
In women, DHEA supplements typically increase androgen levels more significantly than estrogen levels. In men, a reverse trend is noted.
DHEA is also active in the brain, especially in limbic areas, where it may act as a stimulating neuroregulator by opposing GABA activity. It may further enhance cardiovascular health by influencing IGF-1, nitric oxide, and thromboxane A2 levels.
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✅ Description:
DHEA supplementation has shown promise in improving fertility among women with diminished ovarian reserve by increasing the number of eggs and embryos. It may serve as a beneficial nutritional supplement to support the body's natural DHEA functions.
Additional potential applications include support in:
- Cardiovascular disease
- Chronic stress
- Certain cancers
- Weakened immune function
- Cognitive decline and memory loss (e.g., Alzheimer’s)
- Obesity and age-related decline
- Hormonal and mood imbalances
- Osteoporosis and bone health
- Diabetes, depression, erectile dysfunction
- Adrenal insufficiency
- Autoimmune diseases like systemic lupus erythematosus (SLE)
- Allergic conditions
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✔️ Side Effects
Common: Acne, hair thinning, unwanted facial hair growth (in women), mood changes like aggression or irritability, elevated estrogen
Rare: Seek immediate medical help if experiencing symptoms like rapid heartbeat, blurred vision, or dizziness
✔️ Drug Interactions
With medications:
- Calcium channel blockers may raise DHEA levels — use with caution
- Glucocorticoids and insulin can suppress DHEA production
- DHEA may raise triazolam levels
- It inhibits CYP3A, affecting drugs metabolized via this pathway
With food/health conditions:
- May increase insulin sensitivity (in diabetes)
- May exacerbate hormone-sensitive cancers (due to estrogen-like effects)
- Can worsen liver dysfunction
✔️ Contraindications
Not recommended for individuals with a history of psychiatric disorders (e.g., bipolar disorder, mania) or hormone-sensitive cancers due to the risk of triggering symptoms or promoting tumor growth.
✔️ Precautions & Warnings
- Consult a healthcare provider before use if you or your family have a history of breast or prostate cancer, heart conditions, prostate enlargement, or low HDL.
- Avoid in hypertension or thyroid disorders unless closely monitored.
- Do not exceed the recommended dose to avoid potential serious side effects.
✔️ Pregnancy & Lactation
Not safe during pregnancy or while breastfeeding.
✔️ Storage
Store below 30°C, protected from moisture and light. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
